Book the cheapest tickets with Etihad Airways through booking portals as standard, ideally 2-4 months before departure.
Currently, Etihad flies to the nearest airports around the Czech Republic in Munich, Berlin and Vienna. Flights from Prague can be made with a connection in Berlin in cooperation with Air Berlin.
You will be buying tickets mainly to Southeast Asia - Thailand, Malaysia, Indonesia, Sri Lanka, Maldives and the African Seychelles.